CONTRAST

772  patients, ± 28 sites, ongoing until 2010
The Dutch Convective Transport Study (CONTRAST) provides conclusive evidence whether online hemodiafiltration (HDF on-line) leads to a lower mortality and less cardiovascular events as compared to standard low fluxhemodialysis (HD). The primary endpoint is all cause mortality. Secondary endpoints are fatal and non-fatal cardiovascular events.
This randomised double blind multicenter trial (phase III) of 6.5 years, currently includes 772 chronic hemodialysis patients (patients will be included until 31-12-09), randomised between online HDF and standard HD.
Project management, data management and monitoring is performed by the Julius Center. The Julius assistance includes organisation of the investigator meetings, updating the members of the executive committee with site information, organization of an extra instruction visit at the site and intensive contact with the study staff. Furthermore, the Julius Center gives input for the Newsletters and take care of the distribution.

   

    

 

 

Number of enrolled patients during the CONTRAST study.

 

Publications:

van der Weerd NC, Penne EL, Grooteman MPC. Letter to the editor: Effect of hemofiltration (HF) on mortality: no definite answer yet. Am J Kidney Dis. 2009;53:562-3.

 

van der Weerd NC, Penne EL, Bots ML, Van den Dorpel MA, Grooteman MPC, Nubé MJ, ter Wee PM, Blankestijn PJ. Haemodiafiltration: promise for the future? Nephrol Dial Transplant 2008;23:438-443.

 

Penne EL, van der Weerd NC, Grooteman MPC, Blankestijn PJ. Letter to the editor: Results from the RISCAVID study: is haemodiafiltration associated with improved survival? Nephrol Dial Transplant 2008; 23: 3034.

 

Penne EL, Blankestijn PJ, Bots ML, van den Dorpel MA, Grooteman MPC, Nubé MJ, ter Wee PM. The role of on-line hemodiafiltration at reducing cardiovascular morbidity and mortality for chronic hemodialysispatients. Ned Tijdschr Geneesk. 2006;150:1583-5.

 

Penne EL, Blankestijn PJ, Bots ML, van den Dorpel MA, Grooteman  MP, Nube MJ, ter Wee PM; CONTRAST study group. Resolving controversies regarding hemodiafiltration versus hemodialysis: the Dutch Convective Transport Study. Semin Dial. 2005;18:47-51.

 

Penne EL, Blankestijn PJ, Bots ML, van den Dorpel MA, Grooteman MP, Nubé MJ, van der Tweel, ter Wee PM. the CONTRAST study group. Effect of increased convective clearance by on-line hemodiafiltration on all cause and cardiovascular mortality in chronic hemodialysis patients - the Dutch CONvective TRAnsport STudy (CONTRAST): rationale and design of a randomised controlled trial. Curr Control Trials Cardiovasc Med. 2005;6:8.

 

Penne EL, van der Weerd NC, Bots ML, van den Dorpel MA, Grooteman MP, Lévesque R, Nubé MJ, ter Wee PM, Blankestijn PJ. Patient- and treatment-related determinants of convective volume in post-dilution haemodiafiltration in clinical practice. Nephrol Dial Transplant. 2009. [Epub ahead of print]

 

Gritters-van den Oever M, Grooteman MP, Bartels PC, Blankestijn PJ, Bots ML, van den Dorpel MA, Schoorl M, Schoorl M, ter Wee PM, Nubé MJ. Post-dilution haemodiafiltration and low-flux haemodialysis have dissimilar effects on platelets: a side study of CONTRAST. Nephrol Dial Transplant. 2009. [Epub ahead of print]

 

Penne EL, van Berkel T, van der Weerd NC, Grooteman MP, Blankestijn PJ. Optimizing haemodiafiltration: tools, strategy and remaining questions. Nephrol Dial Transplant. 2009. [Epub ahead of print]

 

Penne EL, Visser L, van den Dorpel MA, van der Weerd NC, Mazairac AH, van Jaarsveld BC, Koopman MG, Vos P, Feith GW, Kremer Hovinga TK, van Hamersvelt HW, Wauters IM, Bots ML, Nubé MJ, ter Wee PM, Blankestijn PJ, Grooteman MP. Microbiological quality and quality control of purified water and ultrapure dialysis fluids for online hemodiafiltration in routine clinical practice. Kidney Int. 2009. [Epub ahead of print]

 

Penne EL, van der Weerd NC, van den Dorpel MA, Grooteman MPC, Lévesque R, Nubé MJ, Bots ML, Blankestijn PJ, ter Wee PM. Short term effects of online hemodiafiltration on phosphate control: results from the randomised controlled CONvective TRAnsport STudy (CONTRAST). [Accepted]

 

Penne EL, van der Weerd NC, Blankestijn PJ, van den Dorpel MA, Grooteman MPC, Nubé MJ, ter Wee PM, Lévesque R, Bots ML. Role of residual renal function on decrease of serum ß2 microglobulin levels in patients on online hemodiafiltration. [Accepted]

 

Mazairac AHA, de Wit GA, Penne EL, van der Weerd NC, Grooteman, MPC, van de Dorpel MA, Nubé MB, Buskens E, Lévesque R, ter Wee PM, Bots ML, Blankestijn PJ. Protein-energy nutritional status and disease-specific quality of life in hemodialysis patients. [Submitted]